Assessment of immunohistochemical expression of Minichromosome maintenance protein (MCM-5) in oral squamous cell carcinoma and its clinicopathological correlation

Dr. Pragati Uttam Barge,*
Dr. Jayanti Govind Humbe,
Dr. Mandakini Subhash Mandale,
Dr. Jyoti Dilip Bhavthankar,
Dr. Preshit Laxman Kadam

Abstract

Oral and oropharyngeal carcinomas are common cancers in the world. Therefore, for early diagnosis, prognosis, disease progression monitoring and treatment response, cancer biomarkers are identified as signature molecules. Aim and objectives - To evaluate and compare the immunohistochemical expression of MCM-5 in oral squamous cell carcinoma (OSCC) between clinical stages and its histopathological grades. Study Design - Descriptive cross sectional – in vitro study. Materials and method - This study used immunohistochemistry to examine expression of MCM5 protein in 40 specimens of OSCC and evaluated for localization and staining intensity of MCM-5. Results – Among 40 cases 39 showed positivity of MCM-5 regarding localization, with highly significant (p < 0.001) correlation among all grades (I, II and III) of OSCC. Findings showed, as histopathological grade increased, nuclear expression and immunostaining intensity of MCM-5 also increased. Conclusion – MCM-5 can be promising diagnostic and prognostic markers, as well as potential targets for anticancer therapy.